hCEACAM5/4T1
CBPG0127
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| I. Background | |||
| CEACAM 家族由膜結(jié)合糖蛋白和分泌性糖蛋白組成。膜結(jié)合糖蛋白通過糖磷脂酰肌醇 （GPI）或跨膜結(jié)構(gòu)域錨定在細(xì)胞表面。具有 GPI 錨定的成員主要包括 CEACAM5、 CEACAM6、CEACAM7 和 CEACAM8。CEACAM 5 廣泛表達(dá)于內(nèi)皮細(xì)胞、上皮細(xì)胞、免 疫細(xì)胞等多種細(xì)胞類型表面。CEACAM 5 在正常組織內(nèi)主要作為細(xì)胞粘附分子，介導(dǎo)同質(zhì) 和異質(zhì)性黏附。CEACAM5 編碼的蛋白質(zhì)可以調(diào)節(jié)細(xì)胞分化、凋亡和細(xì)胞極性，從而促進(jìn) 腫瘤的發(fā)展。因此，它也被用作胃腸道癌癥的臨床生物標(biāo)志物。在癌細(xì)胞中，CEACAM5 主要在上皮腫瘤細(xì)胞表面高表達(dá)，包括結(jié)直腸癌、胃癌、胰腺癌、膽囊癌、肺腺癌、小細(xì) 胞肺癌、乳腺癌、膀胱癌、卵。巢癌等 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hCEACAM5 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+2 μg/ml puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |||
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Figure 1. Recombinant hCEACAM5/4T1 stably expressing hCEACAM5. |
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