Mouse CCR9 CHO
CBP71612
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產(chǎn)品描述
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| I. Background | |
| 趨化因子受體 9 （chemokine receptor 9，CCR9），屬于β趨化因子受體家族。它由轉(zhuǎn) 錄本 A（369 個氨基酸，42 kDa）和 B（357 個氨基酸，40.8 kDa）組成。CCR9 主要分布 在未成熟的 T 淋巴細胞和腸細胞表面，結(jié)合其特異性配體，在 T 淋巴細胞發(fā)育和組織特異性歸巢中發(fā)揮作用。研究證明，CCR9 在多種癌癥中高表達，是一種潛在的腫瘤生物標志物，可用于診斷和治療。 CCR9 被其特異性配體 CCL25 激活后，可以與許多信號通路相互作用，特別是與腫瘤化療耐藥和轉(zhuǎn)移有關(guān)的信號通路。 | |
| II. Description | |
Mouse CCR9 CHO 藥靶模型很好的模擬了體內(nèi) CCR9 的信號轉(zhuǎn)導過程，原理見下圖所示。 Figure 1. CCR9 CHO 細胞模型原理圖 |
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| III. Introduction | |
| Expressed gene: |
CCR9 |
| Host Cell: |
CHO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Puromycin |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for Mouse CCR9 |
| Assay Format: | Gi |
| IV. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
V. Representative Data Figure 2.Recombinant Mouse CCR9 CHO stably expressing Mouse CCR9.  Figure 3. HTRF cAMP Assay with Mouse CCR9 CHO(C105). |
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