IL1RAP Jurkat
CBP74523
詢 價(jià)
索取Protocol
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
| I. Background | |
| IL1RAP(白細(xì)胞介素-1 受體輔助蛋白,Interleukin-1 Receptor Accessory Protein)是 IL- 1 受體家族的核心共受體,參與 IL-1、IL-33 和 IL-36 信號(hào)通路的調(diào)控,通過與 IL-1R1、IL- 33R、IL-36R 結(jié)合形成復(fù)合物,激活下游 NF-κB 和 MAPK 通路,驅(qū)動(dòng)炎癥反應(yīng)和免疫調(diào)節(jié)。 在正常生理狀態(tài)下,其表達(dá)水平較低,但在多種疾病中呈現(xiàn)顯著上調(diào),與腫瘤進(jìn)展、自身 免疫疾病及神經(jīng)退行性疾病密切相關(guān)。 | |
| II. Description | |
| IL1RAP Jurkat 細(xì)胞,在 Jurkat 細(xì)胞的基礎(chǔ)上,穩(wěn)定表達(dá)人 IL1RAP。 | |
| III. Introduction | |
| Expressed gene: | IL1RAP |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+10 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
![]() Figure 1. Recombinant IL1RAP Jurkat constitutively expressing IL1RAP. |
|
